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KMID : 0644120200330010001
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Journal of Oriental Gynecology
2020 Volume.33 No. 1 p.1 ~ p.18
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Review for Clinical Studies of Oriental Medicine on the Prevention of Ovarian Hyperstimulation Syndrome
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Ku Su-Jeong
Hwang Deok-Sang
Lee Jin-Moo
Lee Chang-Hoon
Jang Jun-Bock
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Abstract
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Objectives: This review is aimed at assessing the efficacy and effectiveness of oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome (OHSS) through literature research and overview.
Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) on oriental medicine for the prevention of Ovarian Hyperstimulation Syndrome. Studies were searched from Journal of Korean Obstetrics and Gynecology, Korean studies Information Service System, Korean Medical Database, China National Knowledge Infrastructure, Cochrane library, PubMed and EmBase up to 7th November, 2019.
Results: Ten RCTs were finally selected. Eight studies intervened with oral Chinese herb medicine, one is intervened with Chinese medicine enema and the other with acupuncture. Eight studies concluded that intervention with oriental medicine significantly decreased OHSS incidence. Five studies showed significantly higher pregnancy rate in the intervention groups. Two studies reported higher ovulation rate and other two studies showed more maturated eggs than the control groups. Four studies showed opposite results in serum Estradiol level. Vascular Endothelial Growth Factor level was significantly lower in the intervention groups in two studies.
Conclusions: From ten studies, oriental medicine reduced OHSS incidence rate and showed preventable effectiveness. Further strictly designed studies and acupuncture intervened studies are needed to establish evidences.
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KEYWORD
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Ovarian Hyperstimulation Syndrome, Oriental Medicine, In Vitro Fertilization, Randomized Controlled Trials
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